Eporise 4000 IU (erythropoietin)

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In Stock

$150.00$520.00

Injection PriceQuantity
3 Injection/s $150.00
6 Injection/s $280.00
12 Injection/s $520.00

Description

Eporise 4000 IU is a brand name for a pharmaceutical product containing Epoetin alfa, a recombinant form of human erythropoietin. Epoetin alfa is primarily use to treat anemia, especially in patients with chronic kidney disease (CKD), patients undergoing dialysis, or those receiving chemotherapy. Below, I provide a detailed overview of Eporise 4000 IU, including its composition, mechanism of action, indications, dosage, administration, side effects, precautions, interactions, and storage.

Composition

Eporise 4000 IU contains Epoetin alfa as the active ingredient. It is available in prefilled syringes, with each syringe containing 4000 International Units (IU) of Epoetin alfa. The inactive ingredients typically include sodium chloride, sodium phosphate, and human albumin, which stabilize the solution.

How to use Eporise 4000 IU?

Epoetin alfa is a synthetic form of erythropoietin, a glycoprotein hormone that is naturally produced by the kidneys. Erythropoietin plays a crucial role in the production of red blood cells (RBCs) by stimulating the bone marrow to produce and release more RBCs into the bloodstream. Epoetin alfa binds to erythropoietin receptors on the surface of erythroid progenitor cells, promoting their differentiation into mature red blood cells. This process increases the hemoglobin levels and improves oxygen transport in the body.

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Indications

Eporise 4000 IU is prescribed for the treatment of anemia associated with various conditions:

  1. Chronic Kidney Disease (CKD): Patients with CKD often develop anemia due to reduced erythropoietin production by the kidneys. Eporise helps to increase red blood cell production and alleviate anemia in these patients.
  2. Cancer-related Anemia: Chemotherapy can lead to bone marrow suppression, reducing RBC production. Eporise 4000 IU is using to manage anemia in cancer patients receiving chemotherapy.
  3. Anemia in Premature Infants: Premature infants may require erythropoietin therapy to stimulate RBC production, as their bodies are often not fully develop to produce adequate erythropoietin.
  4. Preoperative Use: Eporise is using in patients schedule for major surgery to reduce the need for blood transfusions.

Eporise 4000 IU Dosage and Administration

The dosage of Eporise 4000 IU varies depending on the patient’s condition, weight, and response to treatment. It is crucial to follow the prescribing physician’s instructions. Generally, the initial dose for CKD patients is 50 to 100 IU/kg, administered intravenously or subcutaneously three times a week. The dose may be adjusted based on the patient’s hemoglobin levels, aiming to maintain them within a target range.

In cancer patients, the typical dose is 150 IU/kg subcutaneously three times a week, or 40,000 IU once weekly. For preoperative use, Eporise is usually administered at a dose of 300 IU/kg daily for 10 days before surgery, on the day of surgery, and for 4 days after surgery.

Eporise should be injected into the vein or under the skin, as directed by a healthcare provider. The injection site should be rotated to avoid skin irritation. Proper administration technique is vital to ensure the effectiveness and safety of the treatment.

What are the Side Effects of Eporise 4000 IU?

Like all medications, Eporise 4000 IU can cause side effects. Common side effects include:

  1. Hypertension (High Blood Pressure): Increased red blood cell production can lead to higher blood pressure, especially in patients with chronic kidney disease.
  2. Headache: Some patients may experience headaches, which can manage with over-the-counter pain relievers.
  3. Joint Pain: Arthralgia, or joint pain, is a possible side effect.
  4. Injection Site Reactions: Redness, swelling, or pain at the injection site may occur.
  5. Flu-like Symptoms: Patients may report symptoms such as fever, chills, and muscle pain.

More serious side effects include:

  1. Blood Clots: Epoetin alfa can increase the risk of thromboembolic events, such as deep vein thrombosis, pulmonary embolism, and stroke.
  2. Seizures: In rare cases, patients may experience seizures, particularly if there is a rapid rise in hemoglobin levels.
  3. Pure Red Cell Aplasia (PRCA): This is a rare condition where the bone marrow stops producing red blood cells, leading to severe anemia.

Precautions

Patients should undergo regular monitoring of hemoglobin levels, blood pressure, and other relevant parameters during treatment with Eporise 4000 IU. It is essential to keep hemoglobin levels within the target range to minimize the risk of cardiovascular events and other complications. Eporise is not using in patients with uncontrolled hypertension or those with a history of hypersensitivity to Epoetin alfa or any component of the formulation.

Pregnant or breastfeeding women should only use Eporise under the guidance of a healthcare provider, as the safety of Epoetin alfa in these populations has not fully establish. Additionally, patients should inform their doctors about all other medications they are taking, including over-the-counter drugs and supplements, to avoid potential drug interactions.

Drug Interactions

Eporise 4000 IU may interact with other medications, such as:

  1. ACE Inhibitors: These drugs, used to treat hypertension and heart failure, may diminish the effectiveness of Epoetin alfa.
  2. Cytotoxic Drugs: Chemotherapy agents can reduce the efficacy of Epoetin alfa by directly affecting bone marrow function.
  3. Iron Supplements: While iron is necessary for the production of hemoglobin, it’s crucial to monitor iron levels, as excessive iron can cause toxicity.

Storage

Eporise 4000 IU store in the refrigerator at a temperature of 2°C to 8°C (36°F to 46°F). It does not freeze. If the solution is freeze or expose to light for an extend period, it is discard. Before administration, Eporise is allow to reach room temperature. The syringe should not shake, as this can degrade the active ingredient. Any unused portion of the solution is discard.

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Additional information

Active Ingredient:

erythropoietin

Manufacturer

Emcure Pharmaceuticals Ltd.

Delivery Time

6 To 15 days

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