Rituximab 100 Mg

Description

Rituximab 100 Mg is a monoclonal antibody primarily used in the treatment of certain autoimmune diseases and types of cancer. It specifically targets the CD20 protein found on the surface of B-cells, a type of white blood cell.

How to use Rituximab 100 Mg?

1. Targeting CD20: Rituximab binds to the CD20 antigen on B-cells.
2. B-cell Depletion: Upon binding, rituximab induces the destruction of B-cells through various mechanisms:
   • Antibody-dependent cellular cytotoxicity (ADCC): Immune cells recognize and kill the tagged B-cells.
   • Complement-dependent cytotoxicity (CDC): Activation of the complement system leading to cell lysis.
   • Direct apoptosis: Induction of programmed cell death in B-cells.

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Indications

1. Non-Hodgkin’s Lymphoma (NHL): Use as a first-line treatment, often in combination with chemotherapy.
2. Chronic Lymphocytic Leukemia (CLL): Helps in reducing the number of cancerous B-cells.
3. Rheumatoid Arthritis (RA): Prescribed when other treatments have failed, targeting the autoimmune component by depleting B-cells.
4. Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA): Used in combination with glucocorticoids for induction of remission.

Administration

1. Intravenous Infusion: Rituximab is administer as an IV infusion. The dosage and frequency depend on the condition being treated.
   • NHL and CLL: Typically, an initial dose is followe by subsequent doses at regular intervals.
   • RA: Two doses are give two weeks apart, with subsequent courses administered based on patient response.

What are the Side Effects of Rituximab 100 Mg?

1. Common Side Effects:
   • Infusion reactions: Fever, chills, and rigors during the first infusion.
   • Infections: Increased risk due to B-cell depletion.
   • Fatigue: Generalized tiredness post-infusion.
   • Nausea: Gastrointestinal discomfort.
2. Serious Side Effects:
   • Severe infusion reactions: Hypotension, bronchospasm, and angioedema.
   • Cardiac issues: Arrhythmias and angina, particularly in patients with pre-existing conditions.
   • Progressive Multifocal Leukoencephalopathy (PML): A rare, serious brain infection.
   • Hepatitis B reactivation: Monitoring is essential in patients with a history of hepatitis B.

Precautions and Monitoring

1. Pre-infusion Testing: Screening for hepatitis B virus (HBV) infection and other contraindications.
2. Premedication: Often includes antihistamines, acetaminophen, and corticosteroids to mitigate infusion reactions.
3. Monitoring During Infusion: Close observation for any adverse reactions, particularly during the first infusion.
4. Regular Follow-ups: Blood counts and liver function tests to monitor for side effects and efficacy.

Drug Interactions

1. Live Vaccines: Avoid due to the immunosuppressive nature of rituximab.
2. Other Immunosuppressants: Increased risk of infections; careful consideration needed.

Other Pills:

Rituximab 500 Mg | HUCOG 5000 IU Injection (Human Chorionic Gonadotropin) | HUCOG 10000 HP IU Injection | HCGCAN 5000 IU Injection | HCGCAN 10000 IU Injection