Azipro 250 mg (Azithromycin)

Description

Azipro 250 mg is a medication that contains the active ingredient azithromycin. It is a macrolide antibiotic use to treat a variety of bacterial infections. It is derive from erythromycin and works by inhibiting bacterial protein synthesis, thereby preventing the growth and multiplication of bacteria. Azithromycin binds to the 50S ribosomal subunit of the bacterial ribosome, blocking the translocation of peptides. This action inhibits the assembly of proteins necessary for bacterial survival.

Indications:

• Respiratory Tract Infections: Effective against infections like bronchitis, sinusitis, and pneumonia.
• Skin and Soft Tissue Infections: Used for conditions such as cellulitis and impetigo.
• Sexually Transmitted Infections: Treats chlamydia and gonorrhea.
• Ear Infections: Otitis media in children and adults.
• Throat Infections: Pharyngitis and tonsillitis.

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Azipro 250 mg Dosage and Administration:

• Adults: Commonly, 500 mg on the first day, followed by 250 mg daily for the next four days.
• Children: Dosage is weight-base; usually, 10 mg/kg on the first day, followe by 5 mg/kg for the next four days.
• Administration: This can be take with or without food. It’s crucial to complete the entire prescribe course to prevent antibiotic resistance.

Pharmacokinetics:

• Absorption: Rapidly absorbed with peak plasma concentrations occurring 2-3 hours after administration.
• Distribution: Widely distributed in tissues, with high concentrations in the lungs, tonsils, and prostate.
• Metabolism and Excretion: Metabolized in the liver; excreted primarily in bile and a small amount in urine.

What are the Side Effects of Azipro 250 mg?

• Common Side Effects: Nausea, vomiting, diarrhea, and abdominal pain.
• Serious Side Effects: QT prolongation (heart rhythm disorder), severe allergic reactions, liver dysfunction, and Clostridium difficile-associated diarrhea.
• Less Common Side Effects: Headache, dizziness, and changes in taste.

Contraindications:

• Allergy: Hypersensitivity to azithromycin or any macrolide antibiotics.
• Liver Disease: Severe hepatic impairment.
• Heart Conditions: Caution in patients with a history of QT prolongation or other cardiac arrhythmias.

Drug Interactions:

• Antacids: Can reduce the absorption of azithromycin.
• Warfarin: Potential for increased anticoagulant effects.
• Other QT-Prolonging Drugs: Increased risk of heart rhythm problems.
• Ergotamine: Co-administration can cause ergotism.

Special Populations:

• Pregnancy: Category B – No known risk in humans, but should use only if need.
• Breastfeeding: Small amounts are excrete in breast milk. Caution is advise.
• Elderly: Increased risk of heart-related side effects. Monitoring is recommend.

Storage:

• Store at room temperature, away from moisture and heat. Keep out of reach of children.

Azipro 250 mg Overdose:

• Symptoms of overdose may include nausea, vomiting, diarrhea, and hearing loss.
• Immediate medical attention is required in case of a suspected overdose. Gastric lavage and supportive measures may be employed.

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