Nizonide 500 mg (Nitazoxanide)

Description

Nizonide 500 mg is a prescription medication containing the active ingredient Nitazoxanide. It is commonly use to treat various infections, especially those caused by protozoa and certain types of bacteria. Below is a detailed, pointwise breakdown of the medication:

Active Ingredient and Mechanism of Action

• Active Ingredient: Nitazoxanide
• Mechanism of Action: Nitazoxanide works by inhibiting the pyruvate

  /flavodoxin oxidoreductase (PFOR) enzyme-dependent electron transfer, which is essential for anaerobic energy metabolism in the pathogens. This disruption leads to the death of the parasites and bacteria.

Indications

• Protozoal Infections: Nizonide is effective against protozoal infections such as giardiasis (caused by Giardia lamblia) and cryptosporidiosis (caused by Cryptosporidium parvum).
• Helminth Infections: It can also use to treat infections caused by certain helminths.
• Viral Gastroenteritis: Nitazoxanide has shown efficacy in treating viral gastroenteritis, particularly caused by rotavirus and norovirus.

If you need to buy Doxycycline 100 mg you can purchase now our Generic Cure medicine.

Nizonide 500 mg Dosage and Administration

• Standard Dosage: The typical adult dosage is 500 mg take twice daily (every 12 hours) for 3 days.
• Pediatric Dosage: For children age 1 to 3 years, the dose is usually 100 mg every 12 hours; for children age 4 to 11 years, 200 mg every 12 hours.
• Administration: It should take with food to enhance absorption and reduce gastrointestinal side effects.

Pharmacokinetics

• Absorption: Nitazoxanide is well-absorb when taken with food.
• Metabolism: It is rapidly convert to its active metabolite, tizoxanide.
• Excretion: The drug and its metabolites are primarily excrete through the urine and feces.

What are the Side Effects of Nizonide 500 mg?

• Common Side Effects: These may include nausea, vomiting, abdominal pain, headache, and diarrhea.
• Rare Side Effects: Allergic reactions, dizziness, and changes in urine color can occur but are less common.

Contraindications

• Allergy: Patients with known hypersensitivity to Nitazoxanide or any of the components of Nizonide should avoid this medication.
• Liver or Kidney Disease: Caution is advise in patients with severe hepatic or renal impairment.

Interactions

• Drug-Drug Interactions: Nitazoxanide can interact with other medications, such as anticoagulants (warfarin), leading to altered blood clotting times. It is essential to inform the healthcare provider about all other medications be take.
• Food Interactions: Taking Nizonide with food is recommend for better absorption and to mitigate gastrointestinal discomfort.

Precautions

• Pregnancy and Lactation: The safety of Nitazoxanide during pregnancy and lactation is not well-established. It should be used only if needed and prescribed by a healthcare provider.
• Alcohol: There is no known interaction between Nitazoxanide and alcohol, but it is generally advisable to avoid alcohol when taking any medication to prevent adverse effects and interactions.

Nizonide 500 mg Usage in Special Populations

• Elderly: There is limited data on the use of Nitazoxanide in the elderly. Dose adjustment may be necessary based on overall health and the presence of comorbid conditions.
• Children: Nizonide is used in pediatric patients, with doses adjusted according to age and weight.

Nizonide 500 mg Overdose

• Symptoms: Overdose symptoms may include severe gastrointestinal distress, dizziness, and changes in mental status.
• Management: In case of overdose, supportive measures and symptomatic treatment should be provided. Immediate medical attention is crucial.

Storage

• Storage Conditions: Store Nizonide 500 mg tablets at room temperature, away from moisture and heat. Keep out of reach of children.

Other Pills: 

Cephadex 500 mg | Cephadex DT 250 Mg | Azee 250 mg | Azee 500 mg | Azipro 250 mg | Zpack 500 mg