Rifagut 550 Mg (Rifaximin 550)

Description

Rifagut 550 mg is a medication primarily used to treat hepatic encephalopathy and traveler’s diarrhea. Below is an in-depth, pointwise analysis of this drug.

Active Ingredient and Classification

• Active Ingredient: Rifaximin.
• Drug Class: Antibiotic, specifically a rifamycin derivative.

Mechanism of Action

• Bactericidal Action: Rifaximin works by inhibiting bacterial RNA synthesis, leading to the death of bacteria. It binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, blocking the transcription process.
• Non-Systemic Action: Rifaximin is minimally absorbed into the bloodstream, acting mainly in the gastrointestinal tract. This property makes it effective for intestinal infections and conditions without significant systemic effects.

If you need to buy Cipmox 500  you can purchase now our Generic Cure medicine.

Indications

• Hepatic Encephalopathy: Prevents the recurrence of episodes by reducing the number of ammonia-producing bacteria in the gut.
• Traveler’s Diarrhea: Treats diarrhea caused by non-invasive strains of Escherichia coli.

Rifagut 550 Mg Dosage and Administration

• Standard Dosage: Typically, the dosage for hepatic encephalopathy is 550 mg twice daily. For traveler’s diarrhea, the dosage is 200 mg three times a day for 3 days.
• Administration: Taken orally with or without food. Consistency in timing helps maintain stable drug levels in the body.

Pharmacokinetics

• Absorption: Very low systemic absorption, with about 97% remaining in the gastrointestinal tract.
• Metabolism: Primarily in the intestines, with minimal hepatic metabolism.
• Excretion: Mostly excreted unchanged in feces, with less than 1% excreted in urine.

What are the Side Effects of Rifagut 550 Mg?

• Common Side Effects: Nausea, dizziness, fatigue, peripheral edema, abdominal pain.
• Serious Side Effects: Severe allergic reactions, C. difficile-associated diarrhea, angioedema, and skin reactions.
• Monitoring: Patients should be monitored for signs of allergic reactions and C. difficile infection.

Contraindications

• Hypersensitivity: Contraindicated in patients with a known hypersensitivity to rifaximin, other rifamycin antibiotics, or any component of the formulation.
• Intestinal Obstruction: Not recommended for use in patients with significant intestinal obstruction.

Precautions

• Liver Function: Caution is advise in patients with severe hepatic impairment. Adjustments may be necessary.
• Prolonged Use: Not recommended for more than 14 days due to the risk of developing antibiotic resistance.
• Interaction with Other Medications: Minimal due to low systemic absorption, but care should take with other antibiotics and drugs affecting intestinal flora.

Rifagut 550 Mg Drug Interactions

• Cyclosporine: Increases rifaximin plasma concentrations.
• P-Glycoprotein Inhibitors: May affect the absorption and elimination of rifaximin.
• Antibiotics: Concurrent use may enhance the risk of side effects or alter effectiveness.

Rifagut 550 Mg Use in Specific Populations

• Pregnancy: Classified as Category C. Should use only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding: It is unknown if rifaximin is excrete in human milk. Caution is advise.
• Pediatric Use: Safety and efficacy in children under 12 years have not been establish.
• Geriatric Use: No specific dose adjustment is require, but close monitoring is recommend due to the higher likelihood of concomitant health conditions.

Storage and Handling

• Storage: Store at room temperature (20-25°C or 68-77°F). Keep in a dry place, protected from light.
• Handling: Keep out of reach of children. Ensure the medication is take as prescribe and not share with others.

Other Pills: 

Rifagut 400 Mg | Rifagut 200 Mg | Azicip 250 Mg | Azicip 500 | Azeetop 500 Mg | Azeetop 250 Mg